association of human papilloma virus 16 infection and p53 polymorphism among tobacco using oral leukoplakia patients: a clinicopathologic and genotypic study
نویسندگان
چکیده
background: human papillomavirus (hpv) and p53 alterations are speculated to play a role in carcinogenesis. this study was carried out to find out the association of hpv and p53 with precancerous lesions of the oral cavity such as leukoplakia: the objective of this study was to find the association among human papilloma virus (hpv) 16 infections and p53 polymorphism in tobacco using the oral leukoplakia patients. methods: a total of 91 oral leukoplakia patients and 100 controlswere randomly selected from the out‑patient department of atertiary care dental hospital of north‑east india. blood samples were drawn incisional biopsy was performed from the lesion proper and the tissue was processed for histopathological grading. cytological smears were taken from the lesional site of leukoplakia patients and buccal mucosa of controls. the rate of hpv infection and p53 polymorphism was detected with the help of polymerase chain reaction, gel electrophoresis and deoxyribonucleic acid sequencing. results: the rate of hpv 16 infection was found significantly high in the oral leukoplakia patients. no particular p53 genotype at exon 4 of codon 72 was found to be associated with oral leukoplakia, but “c” allele (proline) at exon 4 of codon 72 was significantly raised in these patients. conclusions: oral leukoplakia, a well‑known pre‑cancerous lesion, has been shown to be associated with tobacco, but certain other factors like hpv infection and p53 polymorphism may play an important role in its development.
منابع مشابه
Association of Human Papilloma Virus 16 Infection and p53 Polymorphism among Tobacco using Oral Leukoplakia Patients: A Clinicopathologic and Genotypic Study
BACKGROUND Human papillomavirus (HPV) and p53 alterations are speculated to play a role in carcinogenesis. This study was carried out to find out the association of HPV and p53 with precancerous lesions of the oral cavity such as leukoplakia: The objective of this study was to find the association among human papilloma virus (HPV) 16 infections and p53 polymorphism in tobacco using the oral leu...
متن کاملOnm-8: Association between Reproductive and Medical and Human Papilloma Virus Infection in Iranian Women
Background: Human Papilloma viruses (HPV) is the most common sexually transmitted infection (STI) and the most important pathogenic factor for cervical intraepithelial lesions and carcinoma therefore a significant source of morbidity and mortality worldwide. This study was designed to investigate reproductive and medical factors associated with HPV infection in women referred to Colposcopy clin...
متن کاملAssociation of Human Papilloma Virus and Epstein-Barr Virus with Ovarian Cancer in Shiraz, Southwestern Iran
Background & Objective: Ovarian cancer is one of the most common cancers amongst women. The association of Human papillomavirus (HPV) and Epstein-Barr virus (EBV) with ovarian cancer is inconclusive; therefore, the aims of this study were to evaluate the frequency of HPV and EBV in malignant, ...
متن کاملTobacco use and oral leukoplakia.
The increase in cancer mortality throughout the world justifies the study of its causes and development. Hungary has the highest mortality rate from oropharyngeal cancer out of forty-six countries. Tobacco use is implicated in the development of oral cancer, and oral leukoplakia as well. The aim of the study was to give an overview of the connection between tobacco use and oral leukoplakia, con...
متن کاملThe relationship among human papilloma virus infection, survivin, and p53 gene in lung squamous carcinoma tissue.
OBJECTIVE To study the relationship between the infection of human papillomavirus (HPV) type 16, type 18, the expression of survivin, and the mutation of p53 gene in lung squamous carcinoma tissue for the research of pathogenesis of lung carcinoma. METHODS This study was carried out at the Laboratory of Molecular Biology, Xiangfan Central Hospital of Hubei Province, China from September 2008 ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
international journal of preventive medicineجلد ۵، شماره ۴، صفحات ۴۳۰-۰
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023